St. Anthony Hospital, the state's oldest hospital, was established in 1898 with 12 beds. Today it is Oklahoma City's largest hospital and the only major hospital still serving the inner city area.

The St. Anthony District has a concentration of medical-related office buildings. Along with St. Anthony Hospital, the area is home to Bone & Joint Hospital, the McBride Clinic, a Physician’s & Surgeon’s Tower, and several other smaller clinics.